Abstract

Background: Perinatal asphyxia is a common neonatal condition and contributes signicantly to neonatal morbidity and mortality. There is a need to identify neonates with asphyxia who will be at risk for hypoxic ischemic encephalopathy (HIE) and multi-organ dysfunction. Objectives: To evaluate prospectively the value of measuring urinary UA/ Cr ratio in early spot urine samples in diagnosing perinatal asphyxia and to assess the relationship between the urinary UA/Cr ratio and the severity of HIE. Methods: The study was conducted in babies born at K V G medical college and Hospital, Sullia from October 2018 to May 2020. The urine sample from 55 asphyxiated neonates comprising cases and 55 comprising controls constituted the material for the study. Results: Urinary uric acid/creatinine ratios were found to be higher in asphyxiated infants (2.58 ± 0.94) when compared to those in control group (0.87 ± 0.17). The cut-off UUA/Cr value of 1.03 has 92.72% sensitivity with a specicity of 76.36% and has a positive predictive value of 79.68% with a negative predictive value of 91.30%. Conclusion: UUA/Cr concentration increase after birth asphyxia and is non-invasive, sensitive and costeffective method for assessment of asphyxia and its outcome.

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