Role of Urinary Transforming Growth Factor-β1 Concentration in the Diagnosis of Upper Urinary Tract Obstruction in Children

Abstract

No AccessJournal of UrologyBasic Science1 Oct 2002Role of Urinary Transforming Growth Factor-β1 Concentration in the Diagnosis of Upper Urinary Tract Obstruction in Children M.T. El-Sherbiny, O.M. Mousa, A.A. Shokeir, and M.A. Ghoneim M.T. El-SherbinyM.T. El-Sherbiny More articles by this author , O.M. MousaO.M. Mousa More articles by this author , A.A. ShokeirA.A. Shokeir More articles by this author , and M.A. GhoneimM.A. Ghoneim More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64416-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluate the role of transforming growth factor-β1 (TGF-β1) in the diagnosis and followup of children with pelviureteral junction obstruction. Materials and Methods: TGF-β1 concentration was measured in renal pelvic and bladder urine samples obtained from 15 children who underwent surgery for symptomatic unilateral pelviureteral junction obstruction. Bladder urine TGF-β1 was also measured in 11 age matched patients with dilated nonobstructed kidneys as documented by nonobstructed washout curve and half-time drainage less than 10 minutes on diuretic renography. In the obstructed group bladder urine TGF-β1 was measured 3 months after surgery. Results: In the obstructed group mean TGF-β1 plus or minus SD in the renal pelvic urine was 285 ± 191 pg./mg. creatinine, or 4-fold that of bladder urine (p >0.001). Mean bladder urine TGF-β1 was 3-fold higher in patients with upper tract obstruction than in controls (68 ± 59 versus 22 ± 18 pg./mg. creatinine, p <0.003). Mean bladder TGF-β1 3 months after surgery showed a trend towards a decrease, albeit still insignificant (68 ± 59 versus 39 ± 31 pg./mg. creatinine for preoperatively versus postoperatively, p <0.08). Using a bladder urine concentration of 29 pg./mg. creatinine as a cutoff between obstruction and no obstruction, TGF-β1 was 80% sensitive, 82% specific and 81% accurate for the diagnosis of obstruction. Conclusions: Bladder urine TGF-β1 is a useful noninvasive tool for diagnosis of upper urinary tract obstruction. At 3 months following corrective surgery there is a trend towards decrease in bladder TGF-β1 concentration in comparison to the preoperative value. References 1 : Outcome analysis of pediatric pyeloplasty as a function of patient age, presentation and differential renal function. J Urol1995; 154: 1889. Link, Google Scholar 2 : Comparison of pediatric renogram and the pressure perfusion study in children. J Urol1985; 134: 92. 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Google Scholar From The Urology and Nephrology Center, Mansoura University, Mansoura, Egypt© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAlmodhen F, Loutochin O, Capolicchio J, Jednak R and El-Sherbiny M (2018) The Role of Bladder Urine Transforming Growth Factor-β1 Concentrations in Diagnosis and Management of Unilateral Prenatal HydronephrosisJournal of Urology, VOL. 182, NO. 1, (292-298), Online publication date: 1-Jul-2009. Volume 168Issue 4 Part 2October 2002Page: 1798-1800 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordshydronephrosis, kidney, ureteral obstructionbladder, transforming growth factor betaMetricsAuthor Information M.T. El-Sherbiny More articles by this author O.M. Mousa More articles by this author A.A. Shokeir More articles by this author M.A. Ghoneim More articles by this author Expand All Advertisement PDF downloadLoading ...