Abstract
Background: Systemic lupus erythematosus often affects the kidneys, and its treatment continues to provide new challenges to clinicians every day. Proteinuria caused by either direct or indirect podocyte damage is diagnostic of lupus nephritis. Aim: The purpose of this study was to evaluate the prognostic usefulness of urinary podocytes in predicting renal complication in individuals with SLE. Subjects and methods: Twenty individuals with SLE participated in this cross-sectional observational research. Complete history collection, clinical examination, and laboratory investigation were performed on all individuals. Podocytes detection in the urine and a kidney biopsy were performed. Results: The relationship between urinary podocytes and histological subtype is quite significant. Also, urinary podocytes significantly positively correlated with all parameters except with albumin significantly negatively correlated. Conclusion: Lupus patients who have renal damage may exhibit urinary podocytes, however this is not a diagnostic indication for lupus nephritis per se. Flares of lupus nephritis may be defined with the use of renal function tests and kidney biopsies.
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