Abstract

Introduction: The early diagnosis of osteoarthritis is required to do possible intervention in early stage of disease because it is one of the leading causes of disability in advance stage. For this reason various biomarker have been studied having merits and demerits of each. We chose urinary CTX-1 as biomarker to assess its role in osteoarthritis in knee joint. Methodology: the study included 100 patients of primary osteoarthritis of knee joint and 50 controls. They were subjected to WOMAC scoring and K-L grading and estimation of urinary CTX-I. Statistical analysis was done using SPSS software version 20.0. Results: Mean CTX-I levels of Control Group were 12.28±5.3ng/dl and in Case Group was 37.13±23.8 ng/dl and this difference was highly significant (p 14.4ng/ml as cut-off point between Control group and Case group. Conclusion: Since CTX-I is biomarker of bone resorption and bone resorption is found more in case of progressive osteoarthritis of knee joint hence, we believe that CTX I levels can help in early identification of progressive OA cases.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.