Role of UPP in evaluating bladder outlet obstruction due to benign prostatic enlargement

Abstract

To study the role of UPP in assessing bladder outlet obstruction (BOO) due to benign prostatic enlargement (BPE). Urodynamic results from 1281 elderly men with Lower urinary tract symptoms (LUTS) obtained from September 1999 through July 2005 were retrospectively analyzed. Independent sample t-test or Wilcoxon signed-rank test was used to compare the parameters of different groups according to PFS. Chi-square test was used to compare the percentage of urethral pressure profile (UPP) types between different groups. ROC curve was used to study the practical value of UPP parameters in diagnosing BOO. According to PFS, patients were divided into three groups: Obstructed, equivocal obstructed and unobstructed. There was significant difference between the unobstructed and obstructed group in the age of patients, bladder capacity, residual volume, voided volume, voided time, prostatic plateau area (PPA), prostatic length, functional profile length, pressure of bladder neck, and pressure of seminal colliculus, but not in maximum urethral closure pressure. All UPP parameters correlated significantly to the diagnosis of bladder outlet obstruction due to BPE. The largest area under the ROC curve was that of PPA. Our results indicate that PPA on UPP is useful in assessing the grade of obstruction due to BPE when PFS fails, a finding still to be evaluated by prospective studies.