Abstract
The TWIST proteins are embryonic transcription factors that play key roles in embryonic development. W hile they remain largely undetectable in healthy adult tissue s, both TWIST1 and TWIST2 genes are frequently reactivated in a wide array of human cancers, where they invariably correlate with more aggressive, invasive and metast atic lesions. In the last decade, the role of TWIST proteins in canc er has been deeply investigated, now offering a gen eral overview how these transcription factors might promote tumor progression. In this review, we aim to summarize t he current state of knowledge on TWIST oncogenic functions and to describe how hijacking embryonic processes by tumor cells is to
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