ROLE OF TRANXEMIC ACID TO REDUCE AND PREVENT POSTPARTUM HEMORRAHGE IN LOW RISK WOMEN

Abstract

Background: To reduce maternal mortality and morbidity caused by bleeding, it is important to reduce the amount of bleeding during and after both normal vaginal delivery and lower segment cesarean section (LSCS). Tranexamic acid helps to reduce bleeding during and after both normal vaginal delivery and cesarean section. Objective: To assess the safety and efficacy of Tranexamic Acid (TXA) in reducing blood loss during and after both NVD and elective CS. Patients and Methods: The current study was conducted as controlled randomized trial on 200 women recruited from labor ward in Assiut Al -Azhar university Hospital. A total number of 100, 50 patients received tranexamic acid before induction of anesthesia in addition to oxytocin after delivery of the baby; in case of elective ceserian section the other 50 patients received tranxemic acid before second stage of labour in NVD the other 100 received only oxytocin after delivery in both NVD and CS. Results: In the current study, there was significant difference between intervention and control groups as regards age. In the current study, no significant difference between intervention and control groups as regards gestational age at delivery (p < 0721 in NVD, p < 0.726 in CS). In the current study, no significant difference between intervention and control groups as regards preoperative hemoglobin (p 0.708 in NVD, p 0.107 in CS). Postoperative hemoglobin was significantly higher in intervention groups than control groups (p < 0.001in NVD, p < 0.021 in CS). In the current study, no significant difference between preoperative and post-operative prothrombin time and INR between intervention groups and control groups both in NVD and CS. In the current study, there was significant difference in postoperative measurements (SBP and DBP) in all groups. Conclusion: The use of tranexamic acid prior to cesarean section and vaginal delivery was significantly effective in reducing blood loss during cesarean section with no observed maternal or neonatal side effects.