Role of Transvaginal Ultrasound in Detection of Endometrial Changes in Breast Cancer Patients under Hormonal Therapy

Abstract

Abstract Background Hormonal therapy is widely utilized as adjuvant therapy in women diagnosed with breast cancer, in those patients, Despite its positive risk/benefit ratio, It may cause secondary effects on the endometrium, Including endometrial atrophy, Endometrial polyp, Endometrial hyperplasia, and up to Endometrial carcinoma. Aim of the Work We aim to determine the role of TVUS in detection of endometrial changes. Aim and Patients and Methods Cross sectional Prospective study. We analyzed the data from previous scans and current scan and correlate it with the results of histopathology. All US examinations were performed by our senior radiologists at radiology department of Helwan university hospital. Study period from March 2018 to November 2018. Results The study group comprised 50 patients with breast cancer who were treated with tamoxifen for a period ranging from 3months to 5 years, by TVUS endometrial thickness measurement was ranging from (3 to 30 mm) the mean is 10.22 mm and standard deviation ± 5.76 mm, all patients were examined by TVUS, gynecological examination and they were candidate for endometrial biopsy either by D&C or hysteroscopic resection. Their histopathology results were: normal endometrium with no changes (52%), endometrial hyperplasia (14%), endometrial polyp (14%), adenomyosis (10%), endometrial atrophy (6%) and endometrial carcinoma (4) %. Conclusion We evaluated the correlation between tamoxifen therapy and endometrial benign and malignant conditions and correlate the findings seen in TVUS by the histopathological results .We concluded that TVUS is a necessary screening tool for detection of endometrial abnormalities in breast cancer patients under hormonal therapy.