Abstract
The potential role of transforming growth factor β (TGFβ) in the regulation of the immunological milieu of the testis was investigated. Antibodies neutralizing TGFβ reversed the previously observed suppression of rat peripheral blood lymphocyte proliferation induced by rat abdominal testis extract. Recombinant TGF β 1 dose-dependently inhibited testicular interleukin-1-like factor-driven proliferation of murine thymocytes and ConA-stimulated rat peripheral blood mononuclear cells. Extracts of seminiferous tubules contained a M r ∼25 K TGFβ-like growth inhibitor of the CLL-64 mink lung epithelial cell line. The present findings suggest an important role for TGFβ in testicular immunosuppression.
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