Abstract
The current analysis aimed to evaluate the role of tranexamic acid in preventing seroma formation after ventral hernia repair. This cross-sectional study was conducted at Bakhtawar Amin Trust Hospital Multan from 20th Jan 2020 to 20th Jan 2021. The study included patients diagnosed with ventral hernia repair. Those with cirrhosis, strangled hernias, uncontrolled diabetes mellitus, and bleeding disorders were excluded. The volume of seroma was measured using a vacuum drain. On the fifth post-operative day, 500 mg of oral tranexamic acid was given for 12 hours, and 1gm of IV tranexamic acid was given after skin closure. Statistical significance was calculated using the Chi-square test. P-value < .05 was considered statistically significant. A total of 110 patients were included in the study. 82 (74.5%) were females, while 28 (25.5%) were male. The patients were aged 45 years. Postoperatively, in 89 patients (81%), the seroma resolved in 5 days; in 21 patients (19%), it took more than 5 days to subside. Tranexamic acid significantly reduces post-operative seroma formation in ventral hernia repair.
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