Role of tranexamic acid in axillary lymph node dissection in breast cancer patients.

Abstract

Axillary lymph node dissection (ALND) is an important step in the management of node-positive operable breast cancer. It is associated with large amount of axillary drainage and increased risk of wound-related infection. Tranexamic acid (TA) has antifibrinolytic property and is being extensively used in controlling blood loss. However, its role in reducing axillary drainage after ALND is still not well-established. The aim of this study is to evaluate the effectiveness of TA in reducing the axillary drainage, early removal of the drain, and decreasing the wound-related infection in breast cancer patients undergoing ALND. This is a prospective nonrandomized double-armed cohort study. Total of 47 patients were included in the TA group and 46 in the nontranexamic (NTA) group. All the patients in TA group received a single dose of intravenous (IV) TA at the time of induction followed by oral TA for five days after surgery. Both TA and NTA groups had similar proportions of locally advanced breast cancers (57.4% vs 56.5%, P=.90). Majority of them underwent modified radical mastectomy (MRM) (70.2% vs 67.4%, P=.76). Patients in TA group had significantly lower axillary drainage (440ml vs 715.5ml, P=.003) with earlier removal of the drain (8 vs 11days, P=.046). Seroma formation (19.1% vs 32.6%, P=.13) and wound-related infection (4.3% vs 8.7%, P=.43) were nonsignificantly lower in the TA group. Tranexamic acid reduces axillary drainage and facilitates early removal of the drain after axillary lymph node dissection.