Role of topical ophthalmic solutions (0.1%) olopatadine hydrochloride and (0.05%) epinastine hydrochlloride in vernal keratoconjuntivitis

Abstract

VKC is of great concern to all ophthalmologists in India because it is found to be quite common in our country and the tropical countries and if untreated it can lead to sight threatening complications.The present study was carried out in fourty patients who attended the outpatient department ophthalmology, Darbhanga Medical College and Hospital, Laheriasarai. The study was carried out from July 2007 Dec 2008. Forty patients with symptoms of VKC (ocular itching, ropy discharge discharge, papillary hypertrophy, gelatinous thickening and (horner-trantas spots) were selected and included in our study. Olopatadine treated group- Means score of itching at 0, 14, 28, 42 days in olopatadine treated eye were 3.2, 2.1, 1.2, and 0.4 respectively having value P<0.01, <0.01 and <0.001 respectively while means score at same stages in Placebo eye were 3.2, 3.1, 3 and 2.6 having p value >0.05. Olopatadine Treated Group-Mean scores of ropy discharge at 0, 14, 28, and 42 days in were 2.9, 2.1, 1.3 and 0.6 respectively having P value <0.01, <0.01, <0.001 and <0.001 in between them and mean scores at same stages in placebo eye were 2.9, 2.8, 2.7 and 2.4 respectively having P value >0.05. It was concluded thatthe present study shown that both olopatadine and epinastine is effective and reducing itching and ropy discharge of VKC as compared to placebo.