Abstract
The diverged homeobox gene TLX1 (for T-cell leukemia homeobox 1, previously known as HOX11 or TCL3) is activated in ∼5-10% of childhood and up to 30% of adult T-cell acute lymphoblastic leukemia (T-ALL) cases, most frequently by t(10;14)(q24;q11) and t(7;10)(q35;q24) chromosomal translocations which juxtapose the intact TLX1 coding region downstream of T cell receptor (TCR) δ (TRD@) or TCRβ (TCRB) gene regulatory sequences. TLX1+ T-ALL samples are virtually all arrested at the early cortical (CD1+) CD4+CD8+ “double-positive” (DP) stage of thymocyte development (Ferrando et al, 2002; Asnafi et al, 2004).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
