Abstract
Chlamydiae are important human pathogens and the leading causative agents for a variety of diseases.Many human diseases caused by chlamydiae are considered to be immunopathologically mediated.Toll like receptors (TLRs) have been proved as the major pattern recognition receptors (PRRs) for many pathogens.TLRs play an important role in the process of initiating innate immune response and establishing adaptive immune responses.Among TLR family,the roles of TLR2 and TLR4 have been extensively studied in chlamydial infection.TLR2 and TLR4 play essential roles for the recognition of chlamydial infection,regulation of the early immune responses and inflammatory reaction.In this article,the roles of TLR2 and TLR4 in immune responses to chlamydial infection were reviewed.A better understanding of the immunological and molecular mechanisms mediated by TLRs will help to explore the molecular targets for immunotherapy and ultimately to control the diseases infected by chlamydiae. Key words: Chlamydia; Toll like receptor 2 ; Toll like receptor 4 ; Immune response; Signaling transduction
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