Abstract
In this investigation, the bioactivity of fluorophosphate glasses with varying titanium dioxide (TiO2) content was evaluated for determining their applications in tissue engineering. For that, a glass system with 48P2O5−29CaO−3CaF2−(20−X)Na2O−XTiO2 (X = 0, 0.5, 1.0, and 1.5 mol%) composition was produced using the standard melt-quenching technique. An ultrasonic pulse-echo receiver was used to evaluate the mechanical strength of titanium-added fluorophosphate glasses (TiFPGs). The in vitro bioactivity of the TiFPG samples was analyzed for 21 days by immersing them in simulated body fluid (SBF). The pH value of the glass immersed in SBF was studied and F– ion release against the immersion days was plotted to assess the dissolution property of the glass. The structural variation in the glass samples as a result of added TiO2 was studied using various characterization techniques namely scanning electron microscopy, energy-dispersive spectrometry, and X-ray diffraction pattern. The biological properties of the TiFPG samples were investigated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The obtained result showed a variation in the mechanical, structural, and biological properties due to the addition of titanium. The fluorophosphate glasses with 1.0 mol% TiO2 content exhibited exceptional and enhanced properties and had a high cell viability percentage.
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