Abstract
Thioredoxin Reductase 1 (TxnRd1) is an essential selenoprotein with well-defined roles in redox regulation of cell growth, death (apoptosis), transcription, DNA repair, and angiogenesis. TxnRd1 is overexpressed in many forms of human cancers and elevated levels of TxnRd1 have been associated with poor prognosis due to enhanced cellular resistance to chemo- and radiation therapy. Chemical inhibitors of TxnRd1 are yielding promising results in preclinical studies and clinical trials as cancer therapeutic agents.
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