Abstract

Prolonged, direct electrical stimulation of vertebrate skeletal muscles induces a state during which contractile force or the capacity to do external work declines after prolonged repetitive stimulation. The muscles then become fatigued or mechanically refractory to further stimulation. Fatigue does not involve permanent impairment of function since contractility can be restored. It is not due to neuromuscular transmission failure1 nor is it caused by a decline in the central nervous system motor drive of muscle. Fatigue is due solely to contractile failure2, 3.KeywordsMyosin Heavy ChainExtensor Digitorum LongusFatigue IndexTetanic TensionFatigue DevelopmentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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