Role of the stromal microenvironment in regulation of medullary hematopoiesis during stress

Abstract

In the modern view an important role in the regulation of function of hematopoietic precursor cells (HPC) is ascribed to the stromal microenvironment in hematopoietic tissue [4]. The chief components of the parenchyma of hematopoietic organs are fibroblasts which, in conjunction with other stromal cells, form specific territories where the ancestral cells of the blood realize their proliferative and differential potential in accordance with the demands of the body as a whole [2, 6]. The most adequate model for the study of the integrativeproperties of thehematopoietic microenvironment in vivo is the method of ectopic bone marrow transplantation [7]. Meanwhile, despite definite progress in the study of the role of stromml cells in the regulation of hematopoiesis in vivo and in vitro, the concrete mechanisms lying at the basis of interaction between stroma and HSC in situ (in particular, when the body is exposed to extremal conditions) remain far from clear [4].