Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis.

Tao Jiang,Guangji Zhang,Zhaohuan Lou

doi:10.3389/fonc.2020.01788

Abstract

Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an essential role in metabolic diseases. In the previous decades, the regulatory range of SREBPs has been markedly expanded. It was found that SREBPs also played a critical role in tumor development. SREBPs are involved in energy supply, lipid supply, immune environment and inflammatory environment shaping in tumor cells, and as a protective umbrella to support the malignant proliferation of tumor cells. Natural medicine and traditional Chinese medicine, as an important part of drug therapy, demonstrates the multifaceted effects of SREBPs regulation. This review summarizes the core processes in the involvement of SREBPs in tumors and provides a comprehensive understanding of the pathways through which natural drugs target the SREBP pathway and regulate tumor progression.

Highlights

Tumors are a major health challenge for humanity, with high annual mortality rates
High levels of fatty acid synthase (FASN) expression have been associated with invasive tumor phenotypes [18, 19], while both acetyl-CoA carboxylase and FASN have been shown to be highly expressed in malignant tumors and are indicators of poor prognosis [7, 20, 21]. These enzymes are regulated by a variety of complex mechanisms, and a large number of studies have shown that Sterol regulatory element binding proteins (SREBPs) are important molecules regulating these key enzymes and leading to lipid metabolism disorders [22,23,24,25,26,27]
There are numerous drugs against SREBPs, their efficacy is limited and insufficient to transform the clinical treatment of tumors

Summary

Introduction

Tumors are a major health challenge for humanity, with high annual mortality rates. In the continuous efforts to discover new treatments for tumors, metabolic changes have been receiving considerable attention. SREBPs in Tumorigenesis shows that tumor cells are involved in a large number of changes in lipid metabolism, which has become one of the important features of tumors [3, 7, 14]. These enzymes are regulated by a variety of complex mechanisms, and a large number of studies have shown that SREBPs are important molecules regulating these key enzymes and leading to lipid metabolism disorders [22,23,24,25,26,27]. Multiple pathways mediated by SREBPs are associated with lipid metabolism and play a role in tumor progression.

Results

Conclusion