Role of the silymarin on the prolactin gene expression in the pituitary, estrogen and progesterone hormones of western rats during lactation

Abstract

Objective: To see how dose of Silymarin aqueous extracts affected prolactin hormone gene expression in pituitary glands and Androgen hormone in serum samples of female experimental rats throughout nursing. Methods: 24 adult healthy, Two sets of pregnant rats were created (12 each group) and treated as follows for ten days postnatal. G 1 were intubated orally distal water serving as control while, G 2 were intubated orally Silymarin (200 mg\kg\day). Results: The findings show that Silymarin had a strong influence on mRNA–PRL expression in pituitary glands, with a rise in Estrogen and a decline in Progesterone levels. Conclusion: The focus of this study mention a new evidence of the role of Silymarin on the prolactin gene expression for increasing the milk production and level of estrogen & progesterone hormones.