Abstract
The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from the peripheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors in the modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonin depletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brain serotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodium depletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesis that the suppression of ascending pathways from the DRN, possibly, 5-HTergic fibers, modifies the angiotensinergic or sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergic blockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked by volume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. In conclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRN and LPBN, for the sodium appetite control.
Highlights
THE ION SODIUM PLAYS CRITICAL ROLE IN THEMAINTENANCE OF THE VOLUME OF EXTRACELLULARFLUID: INFLUENCE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEMThe dynamic balance of the milieu interieur is a sine qua non condition for maintenance of life (Bernard 1878, Andersson 1978, Denton et al 1996, Voisin and Bourque 2002, Weisinger et al 2004)
In which it refers to regulation of the hydroelectrolytic balance it is possible that 5-HTergic activity extends to all levels of coordination of the brain function
While it regulates the electrolytes excretion through the control of the autonomic efferent activity for the renal tubules and through the atrial natriuretic peptide (ANP) secretion, 5-HTergic circuit of DRN, possibly integrated to núcleo parabraquial lateral (NPBL), it would be responsible by stimulation of different mechanisms of sodium appetite inhibition
Summary
THE ION SODIUM PLAYS CRITICAL ROLE IN THEMAINTENANCE OF THE VOLUME OF EXTRACELLULARFLUID: INFLUENCE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEMThe dynamic balance of the milieu interieur is a sine qua non condition for maintenance of life (Bernard 1878, Andersson 1978, Denton et al 1996, Voisin and Bourque 2002, Weisinger et al 2004). These observations raised the hypothesis that DRN neurons, putatively 5-HTergic, regulate the sodium renal excretion through the control of the ANP release (Reis et al 1994).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
