Role of the rs9939609 gene variant of FTO on cardiovascular risk factors and adipokines levels in naive patients with diabetes mellitus type 2

Abstract

One of the genetic variants (rs9939609) of FTO gene is related with obesity and type 2 diabetes mellitus. The aim of the present study was to analyze the relationship of the rs9939609 FTO gene polymorphism to body weight, insulin resistance, cardiovascular risk factors and serum adipokine levels in patients with diabetes. 123 naive patients with diabetes mellitus type 2 were analyzed in a cross sectional design. Body weight, blood pressure, fast blood glucose, c-reactive protein (CRP), insulin, HbA1c, insulin resistance (homeostasis model assessment, HOMA-R), total cholesterol, HDL-cholesterol, HDL-cholesterol, triglycerides blood and adipocytokines levels were measured. Forty one patients (14 males/27 females) (33.3 %) had the genotype TT (wild type group), 51 (11 males/40 females) (41.5 %) TA and 31 (9 males/22 females) (25.2 %) AA (mutant type group). No association between the FTO variant and anthropometric parameters or blood pressure was found. Wild type group had higher HOMA-R (1.3 units:CI95% 0.51–5.8), insulin (3.3 mUI/L:CI95% 0.31–13.4) and triglyceride (12.6 mg/dl: CI95% 3.90–46.1) levels than mutant allelic group (TA and AA). Adipocytokines levels were similar in both genotype groups. The FTO gene polymorphism, rs9939609, was found to be associated with HOMA-R, insulin and triglyceride levels in naive diabetic patients with TT variant.