Abstract
The renin-angiotensin system in relation to arterial blood pressure was examined in conscious rats at various stages of pregnancy. Also, the possibility that a site other than the maternal kidney was the source of the increased plasma renin levels in late gestation was tested by examining the reninangiotensin system in nephrectomized term-pregnant rats. Conscious rats, pregnant for 9, 13, 17, and 21 days, had mean arterial pressures that were not different from those of nonbred control rats; however, infusion of the angiotensin II (A-II) antagonist, [Sar1, Ala8]A-II, resulted in significant decreases in mean arterial pressure in the 13-, 17-, and 21-day-pregnant groups. Pregnant rats had significant elevations in PRA at 13, 17, and 21 days of gestation and increases in plasma renin concentrations (PRC) at 13 and 21 days of gestation, while plasma renin substrate concentrations (PRS) were significantly increased in the 9- and 13-day-pregnant groups, but were not increased in the 17- and 21-day-pregnant gro...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
