Abstract
The innate immune system and its components, such as inflammasomes, are involved in the pathogenesis of several infectious, autoinflammatory, malignancies, and autoimmune disorders. Based on available knowledge, among these inflammasomes, the NLR family pyrin domain containing 3 (NLRP3) is well-studied and responsible for producing inflammatory cytokines, including interleukin-1 beta (IL-1β) and IL-18. The NLRP3-mediated hyper inflammation could be involved in different pathologic states such as Muckle-Wells syndrome (MWS), cryopyrin-associated periodic syndrome (CAPS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Alzheimer's disease (AD), type 2 diabetes mellitus (T2D), cardiovascular diseases (CVDs), and infectious diseases. Previous studies reported that NLRP3 rs35829419 (Q705K), rs10925019, rs10754558, rs4925648, and rs4612666 are associated with chronic inflammatory states. According to the latest evidence, The Q705K, a well-studied gain-of-function polymorphism, could be associated with the pro-inflammatory phenotype. However, the outcomes of studies on the Q705K polymorphism and its association with various chronic inflammatory diseases are contradictory. On the other hand, these genetic alterations can affect the treatment of inflammatory diseases. Therefore, this review summarized the role of NLRP3 inflammasomes and Q705K polymorphism in the pathophysiology of various inflammatory mediated diseases. Furthermore, challenges of treatment, especially immunotherapy in inflammatory-mediated cancers, are discussed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
