Abstract
The hydrolysis kinetics of spread insoluble monolayers of poly(α-hydroxy acid)s with various molecular weights and lactic acid–glycolic acid molar ratios was followed by measuring simultaneously the decrease in the surface area at constant surface pressure and the evolution of the surface potential. The interfacial hydrolysis at alkaline pH leads to the progressive fragmentation of the polymer molecules and the appearance of charged insoluble products (detected by measuring the surface potential) and small soluble fragments (detected by measuring the decrease in the surface area). The data obtained by both approaches were interpreted in the framework of the random scission model. The rates of hydrolysis are larger for polymers with smaller initial polymerization numbers and increase with the decrease in the molar ratio of lactic acid units.
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