Abstract
Differential diagnosis between pulmonary tuberculosis (TB) and community acquired pneumonia (CAP) is often difficult. Pulmonary TB could induce a systemic hypercoagulable state. The present study aims to investigate whether fibrinogen degradation products (FDP) and D-dimer play a diagnostic role for pulmonary TB. We retrospectively analyzed the clinical and laboratory characteristics of 192 patients with activated pulmonary TB and 110 patients with CAP. The serum levels of FDP and D-dimer were detected and the diagnostic ability was evaluated. The serum levels of FDP and D-dimer were significantly higher in patients with pulmonary TB compared to CAP (both p < 0.05). ROC curve analyses showed that the diagnostic value of FDP in pulmonary TB was noticeably higher than that of D-dimer (p = 0.0197). Combined detection of FDP and D-dimer may slightly improve the sensitivity of diagnosis for pulmonary TB from CAP. However, the AUC showed no significant differences from FDP alone (p = 0.416). The serum level of FDP and D-dimer are useful laboratory markers that can be used to distinguish patients with pulmonary TB from patients with CAP.
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