Abstract
Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
Highlights
Bile acids (BA) are signaling molecules with pleiotropic paracrine and endocrine functions
Cholangiocytes were cultivated from isolated ducts from livers of TGR5 wildtype and knockout mice and cell proliferation was measured by BrdU incorporation after stimulation with bile acids or specific TGR5 agonists
Bile acid feeding resulted in more elevated liver function tests in TGR5 knockout mice as compared to their wildtype littermates on the same diet
Summary
Bile acids (BA) are signaling molecules with pleiotropic paracrine and endocrine functions (for recent reviews see [1,2,3,4] and references ). The farnesoid X receptor (FXR, NR1H4) is a ligand activated transcription factor responsive to different bile acids and highly expressed in hepatocytes. The expression pattern in different nonparenchymal cells of the liver as well as the anti-inflammatory, anti-apoptotic, choleretic and proliferative functions of TGR5 suggest a role for this bile acid receptor in liver injury as well as in liver regeneration [1,3].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
