Abstract
Role of TGF-β/Smad Signaling Pathway-Related Proteins in Clinicopathological Features and Prognosis and Survival of Patients with Nasopharyngeal Carcinoma
Highlights
Nasopharyngeal carcinoma (NPC) ranks the 11th common cancer with high incidence in China, with the rate of approximately 2.8/100,000 among men and about 1.9/100,000 among women [1]
Our study suggests that NPC presents with up-regulated expression of positive expression rates of TGF-β1 and Smad7 and down-regulated TGF-β2, TGF-βRII, Smad4 and RUNX3, and TGF-β1, TGF-β2 and Smad4 are independent factors for the prognosis of NPC, which could be regarded as the novel target for the treatment of NPC
The results showed that, TGF-βRI expressed mainly in the cytoplasm and nucleus, TGFβRII expressed mainly in the membrane and cytoplasm, Smad4 protein expressed in the cytoplasm and within the nucleus, TGF-β2, Smad7 and RUNX3 expressed in the cytoplasm with positive signals localized in the cytoplasm
Summary
Nasopharyngeal carcinoma (NPC) ranks the 11th common cancer with high incidence in China, with the rate of approximately 2.8/100,000 among men and about 1.9/100,000 among women [1]. NPC has obvious geographical distribution characteristics, mostly occurred in the southern area of China [2]. NPC is caused by the risk factors of Epstein-Barr virus (EBV), genetic predisposition, smoking and alcohol [3]. Radiotherapy is the basic clinical treatment for patients with early NPC, and intensive modulated radiation therapy (IMRT) involved with a variety of systemic therapy has demonstrated a significant effect in recent years [4]. The local control rate of IMRT for NPC can reach up to 90%, the prognosis of NPC reduced considerably [5]. The signaling pathway for the regulation of NPC caused extensive concern
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