Abstract
INTRODUCTION. Telomeres and telomerase expression have been implicated in neoplastic progression of human tumors and in replicative senescence of cultured cells. However, their role in replicative senescence and aging of cell populations in vivo is less certain, despite the fact that human telomere length is age-related in rapidly dividing tissues such as hematopoietic cells (1). Given that relatively short-lived inbred mice have telomeres several times longer than humans, the relevance of telomere shortening to aging in mice is even more doubtful. Using a Flow cytometry-based fluorescence in situ hybridization (Flow-FISH) method of measuring telomere length in individual cells, we have studied the effects of aging and sublethal irradiation on hematopoietic cells of long-lived (C57BL/6) and short-lived (DBA/2) mouse strains.
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