Role of TE in MR Spectroscopy for the Evaluation of Brain Tumour with Reference to Choline and Creatinine

Abstract

Background: The brain tumour is the most typical neurological disease in the human. The brain tumourcauses partial paraplegia, memory loss and various kinds of neurological disorder which causes changesof metabolic process in the brain, integrity of neurons, cells proliferation and detoriation. For accuracy indetection, patient will undergo MR Spectroscopy (MRS) based on MR imaging will enhance more widelyused clinical applications and is capable to gives details information about metabolite properties in thebrain of normal and abnormal tissue morphology. MRS is the non-invasive procedure may provide detailsand accuracy about the metabolites in the brain tumour. This study aims to detect efficacy of short andintermediate TE in evaluation of brain tumour with reference to choline and creatinine using multivoxelMRS technique.Method: The total participants (n = 75) with the brain tumour will be included randomized scan under theMRI with a customised protocol. We will be applying two various types of multivoxel MR sequence witha short TE and intermediate TE. Both sequence applying on each participant of brain tumour with coverproper saturation band and after the post processing we will evaluate choline and creatinine metabolite andmeasured the exact variation between given values.Expected Results: MR Spectroscopy may allow the noninvasive separation of high-grade tumour from thelow-grade tumour. Choline and Creatinine ratios may show the steady results in concluding the grade oftumour. The Intermediate TE may show more accuracy, sensitivity and specificity as compared with shortTE.