Abstract
1. Taurine levels were determined in the heart, brain, and red and white muscle of turkey poults fed furazolidone (FZ) at a dose of 700 ppm from 2 to 5 weeks of age and/or 0.1 M taurine from 1 to 5 weeks of age. 2. In FZ-fed poults, taurine levels in the myocardium decreased significantly ( P < 0.001), but not in brain or muscle indicating a specific effect of FZ on the heart. 3. Exogenous administration of taurine significantly ( P < 0.001) increased taurine content of brain and muscle in all poults. 4. Myocardial taurine levels were significantly elevated ( P < 0.01) in poults fed a normal ration, but not in those fed FZ. 5. Although taurine treatment restored myocardial taurine to normal levels in the FZ-fed poults, the treatment did not decrease the incidence of FZ-induced cardioyopathy. 6. Since taurine is a membrane stabilizer and protects against calcium overload, our data suggests that sarcolemmal damage leading to tissue calcium overload is not the mechanism of the furazolidone-mediated syndrome.
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