Abstract

 
 
 Contrast-induced nephropathy (CIN) is the third considerable cause of acute kidney injury (AKI) and makes up almost 10% of all acute kidney failure (AKF) cases.Objective. To study the role of polymorphism of eNOS-gene in the development of acute contrast-induced nephropathy (CIN) in case of coronary heart disease.Materials and methods. The prospective study was conducted in the National Cardiology and Therapy Center named after academician Mirsaid Mirahimov from 2015 to 2018. A total of 184 patients with coronary heart disease (CHD) aged 33-70 years (average age 55.2 ± 8.5 years) were examined to determine possible associative relationships between eNOS gene polymorphism (T786C) and the development of acute CIN. Of these, the group without CIN was 152, and with the CIN there were 32 patients who underwent coronary angiographic examination (CAG). Radiopaque contrast agents Ultravist (Iopromide) and Omnipack (Iohexol) were used. CIN was defined as an increase in serum creatinine (Scr) concentration by more than 25% from the initial level or by more than 0.5 mg/dL (44.2 μmol/L) and a decrease in glomerular filtration rate (GFR) after administration of an iodinated contrast agent within 48-72 hours in the absence of other reasons. A molecular genetic study was conducted to determine the T-786C polymorphism of the eNOS gene.Results. The genotype frequency of the TT gene in the group with CIN was 87.5%, and in the group without CIN 69.7%, the reliability was p <0.05. But the connection of acute CIN with the genotypes of TS and SS was not observed in both of the groups.Conclusions. TT genotype T-786C polymorphism of the eNOS gene is a risk factor for the development of acute contrast-induced in patients with coronary heart disease.
 
 
Highlights
Contrast-induced nephropathy (CIN), called contrast-induced acute kidney damage (CI-acute kidney injury (AKI)), is an iatrogenic disease that occurs after administration of an iodinated contrast agent in the absence of other causes [1,2], which appears as an AKI that occurs in within 24-72 hours after intravenous or intraarterial administration of X-ray contrast agents (CSWs), the diagnostic criteria of which are an increase in
In 2004, Gleeson and Bulugahapitiya [4] indicated that CIN is the third considerable cause of acute kidney failure (AKF) that developes in the hospital after invasive procedures and hypotension, and causes 12% of all AKI-cases in the hospital
We studied the frequency of contrast-induced nephropathy in patients with coronary heart disease during endovascular interventions when contrast agents − iopromide (Ultravist) and Omnipack (Iohexol) were used
Summary
Contrast-induced nephropathy (CIN), called contrast-induced acute kidney damage (CI-AKI), is an iatrogenic disease that occurs after administration of an iodinated contrast agent in the absence of other causes [1,2], which appears as an AKI that occurs in within 24-72 hours after intravenous or intraarterial administration of X-ray contrast agents (CSWs), the diagnostic criteria of which are an increase in. Objective: To study the role of endothelial NO synthase gene polymorphism in the development of acute contrast-induced nephropathy in coronary heart disease. The first group included 32 patients who, after endovascular intervention for coronary heart disease, developed contrastinduced nephropathy (CIN).
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