Abstract
Functional immune cells are required for the prevention or resolution ofimmune-mediated disease , in particular T cells, including helper (CD4+; Th) or cytotoxic (CD8+; Tc) T cells. Th cells differentiate into Th1 or Th2 type cells, through production of inflammatory (IL-2, IFN-a) or anti-inflammatory (IL-4, TGF-ß) cytokines, respectively. Th cells also can differentiate into a third type of Th cells termeds Th17 type cells that produces IL-17 thereby mimicing the effects of Th1 cells. Th type cells can also differentiate under certain conditions into a regulatory (T-reg) type cell capable of secreting immunosuppressive cytokines such as TGF-ß and IL-10. This mini-review discusses the importance of T cell plasticity in regulating the nature of the immune cell responses seen in inflammatory diseases or cancer.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.207-211
Highlights
Functional immune cells are required for the prevention or resolution ofimmune-mediated disease, in particular T cells, including helper (CD4+; Th) or cytotoxic (CD8+; Tc) T cells
Leukemia: Leukemia is a malignant leukocyte disease characterized by uncontrolled cell proliferation, reduced apoptosis and, in certain types of leukemia, insufficient differentiation that results in normal leukocyte displacement and increased numbers of malignant cells found in the bone marrow and in peripheral blood
We investigated this hypothesis by examining the role of T cells in the chronic phase and/or blast crisis phase of CML relapse following either bone marrow transplantation and/ or chemotherapeutic treatment
Summary
Functional immune cells are required for the prevention or resolution ofimmune-mediated disease , in particular T cells, including helper (CD4+; Th) or cytotoxic (CD8+; Tc) T cells. Prince Sattam bin Abdulaziz University (PSAU) Saudi Arabia Email: fqalenzi@ ksu.edu.sa CD4+CD25+ T cells might have an important role in facilitating immune tolerance through regulation of those T cells responsible for autoimmune disease[6].
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