Abstract
Role of Systemic Antibiotics in the Management of Periodontal Diseases
Highlights
The word antibiotic derives its name from two Greek words anti and bios meaning against life
An adequate knowledge about the host, bacterial and drug factors are essential before prescribing systemic antibiotics
This review presents the basic rationale and the factors to be considered behind prescribing systemic administration of antibiotics in the treatment of periodontal diseases
Summary
The word antibiotic derives its name from two Greek words anti and bios meaning against life. This review presents the basic rationale and the factors to be considered behind prescribing systemic administration of antibiotics in the treatment of periodontal diseases. Post antibiotic effect Certain drugs like azithromycin possess post antibiotic effect and enhance the activity of cells like leukocytes This should be taken into consideration while prescribing these drugs. Some drugs bind to plasma proteins making their bioavailability low. This factor is more important in treating patients with hepatic or renal. The plasma protein binding of commonly prescribed drugs is given below. Clindamycin and metronidazole usually do not require dose alterations in renal failure This binding increases with infection, diabetes, malignancy decreases with liver disease, burns and malnutrition. Clinical improvement of the patient as judged by remission of infection must be assessed before discontinuing the drug
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