Abstract
A comparative study of the effect of cortisone on β-galactosidase synthesis in strains ofEscherichia coli K-12 with an induced (E. coli 200 PS/F lac), a constitutive (E. coli ML-308), and a superrepressed (E. coli 2000 iS) type of enzyme synthesis and in rat liver cells showed that the hormone itself has no derepressive effect. In all cases an increase in β-galactosidase synthesis takes place only in the presence of the specific substrate inducers. It is suggested that the principal stage in the mechanism of action of cortisone on the lactose operon ofE. coli and on enzyme production in rat liver cells is the preliminary derepression of regions of the genome through substrate inducers.
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