Role of substance P in the regulation of obstructive sleep apnea hypopnea syndrome

Abstract

Substance P is a eleven amino acid polypeptide, are widely distributed in the nervous system and other peripheral organs and tissues, the G protein coupled receptor neurokinin 1 receptor distributed in the ventral and dorsal nerve of tongue. Substance P is not only a neuropeptide, but also an immunomodulatory factor, mediating neurogenic inflammation, inducing a variety of inflammatory mediators, mediating leukocyte infiltration and participating in the pathological process of respiratory inflammatory diseases. Obstructive sleep apnea syndrome in patients with soft palate, uvula and tongue mucosa due to nerve damage hypopnea syndrome, inflammatory propeptide leads to the increase of pathological changes of neurogenic inflammation, resulting in pharyngeal airway volume decrease or occlusion, leading to increased inspiratory airway resistance in patients with OSAHS when. When the upper airway muscles are innervated by the denervation, there will be a lack of neuromuscular compensation when the upper airway is blocked. These changes may play a role in the pathogenesis of 0SAHS. This review is a review of the relationship between substance P and its receptors and obstructive sleep apnea hypopnea syndrome. Key words: Substance P; Neuropeptides; Sleep Apnea, Obstructive; Hypoglossal Nerve