Abstract
There are at least two mechanisms by which H 2O 2 induces DNA lesions in Escherichia coli: one in the presence of physiological iron levels and the other in low iron conditions. The survival as well as the induction of SOS response in different DNA repair mutant strains of E coli was evaluated after H 2O 2 treatment under low iron conditions (pretreatment with an iron chelator). Our results indicate that, in normal iron conditions RecA protein has a relevant role in recombination repair events, while in low iron conditions ReA protein is important as a positive regulator of the SOS response. On the other hand, the oxyΔR mutant is sensitive to the lethal effects of H 2O 2 only in low iron conditions and this sensitivity cannot be correlated with DNA strand breaks.
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