Abstract
BackgroundSeveral factors affect acute ischemic stroke (AIS) outcomes.ObjectiveThis study aimed to assess the role of the leukocyte count, neutrophil/lymphocyte ratio (NLR), and c reactive protein (CRP) as early predictors of outcome in AIS patients.MethodsThis study was conducted on 60 AIS patients. They were subjected to detailed history taking, clinical examination, brain imaging, and laboratory assessment including the CRP, white blood cell (WBC) count, absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and NLR which is calculated by dividing ANC by ALC. Neurological scales were used to assess the level of consciousness by the Glasgow Coma Scale (GCS) and stroke severity by the National Institute of Health Stroke Scale (NIHSS) at the first 48 h of stroke onset as well as 1 week and 2 weeks later for the assessment of short-term functional neurological outcome.ResultsSixty percent of the patients had unfavorable outcomes assessed by the Modified Rankin Scale (mRS). Patients with unfavorable outcomes had higher NIHSS scores. NLR was positively correlated with WBC count, ANC, and CRP. The higher WBC, NLR, and NIHSS, the unfavorable the outcome was.ConclusionThe higher WBC, the NLR, and the level of CRP at the onset of AIS, the more severe stroke and the poorer the short-term outcome are expected.
Highlights
IntroductionAcute ischemic stroke is one of the major causes of death worldwide, and due to the high mortality and morbidity rates associated with stroke, it is becoming a major community health problem worldwide as the third of these cases are fatal and survivors usually have prolonged or irreversible disabilities [1]
Acute ischemic stroke is one of the major causes of death worldwide, and due to the high mortality and morbidity rates associated with stroke, it is becoming a major community health problem worldwide as the third of these cases are fatal and survivors usually have prolonged or irreversible disabilities [1].Several factors affect stroke prognosis including age, stroke severity, lesion location, comorbid conditions, clinical findings, and related complications
neutrophil/lymphocyte ratio (NLR) was positively correlated with white blood cell (WBC) count, absolute neutrophil count (ANC), and c reactive protein (CRP)
Summary
Acute ischemic stroke is one of the major causes of death worldwide, and due to the high mortality and morbidity rates associated with stroke, it is becoming a major community health problem worldwide as the third of these cases are fatal and survivors usually have prolonged or irreversible disabilities [1]. Several factors affect stroke prognosis including age, stroke severity, lesion location, comorbid conditions, clinical findings, and related complications. Knowledge of the factors contributing to early neurologic deterioration after. AIS can guide the early management strategies and lead to more favorable outcomes [2]. Several factors affect acute ischemic stroke (AIS) outcomes
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