Abstract
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF). The culture system using a combination of sIL-6R, IL-6 and SCF can be useful for ex vivo expansion of human hematopoietic stem/progenitor cells and provide a novel way for gene transfer into human hematopoietic stem cells.
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