Abstract

Background and Objectives: The small proline rich protein (SPRR) genes constitute a family of conserved genes which are part of the human epidermal differentiation complex (EDC) on chromosome 1q21 and code for precursor proteins of the cornified cell envelope. The expression of these genes is strictly linked to keratinocyte terminal differentiation The objective of this study was to compare the expression of SPRR2 in normal buccal mucosa, and various grades of dysplasia and oral squamous cell carcinoma.

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