Abstract
Background: The principal aim of this study was to measure the effect of online single-pulse transcranial magnetic stimulation (TMS) over the right dorsolateral prefrontal cortex (DLPFC) on cognition via the Cambridge Neuropsychological Test Automated Battery (CANTAB) in healthy individuals.Methods: In a single-blind, sham-controlled study, we assessed both 50% and 60% of the resting motor threshold (RMT) over the right DLPFC in healthy right-handed (n = 42) adults using cognitive function, such as attention and memory, as a measure via CANTAB.Results: We observed an improvement in the cognitive function level during the use of online low intensities of 50% and 60% RMT active stimulation of the DLPFC compared to the sham stimulation.Conclusions: The results showed that low-intensity TMS can indeed effectively modulate cognitive function in DLPFC. Future research is, however, necessary to investigate the potential effects of low-intensity TMS on different brain areas to increase confidence in the observed results.
Highlights
The principal aim of this study was to measure the effect of online singlepulse transcranial magnetic stimulation (TMS) over the right dorsolateral prefrontal cortex (DLPFC) on cognition via the Cambridge Neuropsychological Test Automated Battery (CANTAB) in healthy individuals
We observed an improvement in the cognitive function level during the use of online low intensities of 50% and 60% resting motor threshold (RMT) active stimulation of the DLPFC compared to the sham stimulation
The results showed that low-intensity TMS can effectively modulate cognitive function in DLPFC
Summary
The principal aim of this study was to measure the effect of online singlepulse transcranial magnetic stimulation (TMS) over the right dorsolateral prefrontal cortex (DLPFC) on cognition via the Cambridge Neuropsychological Test Automated Battery (CANTAB) in healthy individuals. The literature includes reports of TMS either improving or impairing cognitive performance in terms of response time (RT; Boroojerdi et al, 2001; Drager et al, 2004) and memory tasks (Cappa et al, 2002; Luber et al, 2007a; Boyd and Linsdell, 2009). Previous work on TMS has presented conflicting results in terms of increasing or decreasing cognitive performance in task-related perception, attention, conceptualization, memory, reasoning, and motor performance (Pascual-Leone and Hallett, 1994; Evers et al, 2001; Cotelli et al, 2006, 2011; Cattaneo et al, 2008, 2009a,b, 2010). We focused mainly on the effects of low-intensity online TMS via a single pulse over the frontal cortex
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