Role of silymarin on the some serum sex hormones and oxidant\ antioxidant parameters in during Lactation period on female rats

Abstract

Objective: To see how dosage of Silymarin effect on some serum prolactin ,estrogen and progesterone and some oxidant\ antioxidant in serum samples of female experimental rats throughout nursing. Methods: Twenty-four adult healthy, pregnant rats were divided into two groups (12rats/group) and treated as follows for ten days. G 1 were intubated orally distal water serving as control while, G 2 were intubated orally Silymarin (200 mg\kg\day), the following criteria were measured serum prolactin, estrogen, progesterone hormones, GSH, MDA, SOD and CAT. Results: The findings show that Silymarin had a significant increase influence in serum prolactin, estrogen hormone, SOD, CAT, MDA and a significant decrease in Progesterone and GSH. Conclusion: The focus of this study mention a new evidence of the role of Silymarin on the increasing prolactin, estrogen & progesterone hormones hormone and effect on some level of oxidant\ antioxidant.