Role of Silver Nanoparticle-Doped 2-Aminodiphenylamine Polymeric Material in the Detection of Dopamine (DA) with Uric Acid Interference.

Harjot Kaur,Reena V Saini,Walaa F Alsanie,Karamveer Sheoran,Vijay Kumar Thakur,Adesh Kumar Saini,Samarjeet Singh Siwal

doi:10.3390/ma15041308

Abstract

A viable electrochemical approach for the detection of dopamine (DA) in uric acid (UA) utilizing a silver nanoparticle-doped 2-aminodiphenylamine (AgNPs-2ADPA) electrode was invented. The electrochemical performance of DA showed that the incorporated electrode displayed outstanding electrocatalytic performance to the electrochemical oxidation of DA. In our study, the AgNPs-2ADPA exhibits remarkable catalytic activity, retaining high current value and resilience when employed as a working electrode component for electrocatalytic detection of DA. We have also utilized the bare and polymeric-2ADPA in DA detection for a comparison study. This method offers a facile route with extraordinary sensitivity, selectivity, and strength for the voltammetric detection of DA, even in the presence of UA and ascorbic acid (AA) as interferents, that can be employed for pharmaceutical and biological specimens.

Highlights

3,4-Dihydroxyphenylethylamine, generally named dopamine (DA), has attracted neuroscientists and researchers since its discovery in the 1950s [1]
Dopamine is a neurotransmitter produced in the central nervous system, that acts by binding to DA receptors
This investigation offers a facile route for the voltammetric detection of DA wit extraordinary sensitivity, selectivity, and strength with uric acid (UA) and ascorbic acid (AA) as interferents that can be employed on pharmaceutical and biological specimens

Summary

Introduction

3,4-Dihydroxyphenylethylamine, generally named dopamine (DA), has attracted neuroscientists and researchers since its discovery in the 1950s [1]. DA is an electroactive and essential neurotransmitter, enabling neuronal transmission in the physiological system as a significant neurochemical [5] It serves as an extracellular chemical courier in the cardiovascular, renal, hormonal, and primary nervous systems [4]. To improve the sensitivity of non-enzymatic sensors for DA detection, multiple functionalized electrodes, like graphene (Gr), carbon nanotubes (CNTs), conducting polymers (CPs) materials, and nanostructured metal oxides (MOx), offering increased electrocatalytic performance, were used to enhance DA detection [9,10,11]. The bare and polymeric-2ADPA electrodes were utilized in DA detection for comparison purposes This investigation offers a facile route for the voltammetric detection of DA wit extraordinary sensitivity, selectivity, and strength with UA and AA as interferents that can be employed on pharmaceutical and biological specimens

Methods

Results

Conclusion