Abstract
Silica nanoparticles (SNPs) were synergistically integrated with long-period grating (LPG) platform and the process of layer-by-layer (LbL) assembly to enable monitoring controlled release of drug-eluting polyelectrolyte coatings. The SNPs afforded a high surface area for increased drug loading as well as enhanced evanescent field overlap. In addition, the SNPs positioned within the LbL coatings acted as diffusion barrier layer, leading to prolonged release profile. SNPs with different sizes were respectively immobilized on the LPG using poly allylamine hydrochloride (PAH). In-situ monitoring of drug-eluting LbL coating [chitosan (CHI)/Poly arylic acid (PAA)/Gentamicin sulfate (GS)/PAA]n was carried out on LPG with a sensitivity of 8.1nm shift/tetralayer for LPG with 1 layer of SNPs with 50nm in diameter. LPG without the SNPs for the monitoring of [CHI/PAA/GS/PAA]n shows a sensitivity of 2.4nm shift/tetralayer, indicating the significant ability of SNPs in enhancing the LPG sensitivity. Drug release measurement carried out on the LPG platform revealed an increased release time for LbL-SNP drug delivery system compared with that of LbL alone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
