Abstract
Recent molecular and genetic studies have demonstrated that early oligodendrocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) protein produced in the ventral midline structures. Whilst Shh signalling is required for ventral oligodendrogenesis in the entire central nervous system, Gli2 activity only regulates oligodendrocyte development in the ventral spinal cord. Gli3 plays a nonessential role in ventral oligodendrogenesis during normal development. However, in the absence of Shh signalling, Gli3 functions as a repressor of ventral oligodendrogenesis. In addition, there is growing evidence that a separate population of oligodendrocyte progenitor cells is also produced from the dorsal region of the neural tube independent of Shh signalling.
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