Abstract
Background: The aim of the present study was to determine whether there were any changes in serum zinc level in children with febrile seizure in comparison with febrile children without seizure.
 Methods: A prospective observational study was done on 100 children, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 subjects using calorimetric methods. Data was analyzed using SPSS version 22.
 Results: In present study, we studied 50 children (36 males, 14 females) with febrile seizure and a control group of 50 patients (37 male, 13 female). The mean ages of patients in the febrile seizure and control group were 25.01±14.07 months and 26.07±13.6 months, respectively. Mean zinc level was 69.78±13.13mcg/dl and 80.72±10.21 mcg/dl in study and control groups respectively and this difference was found statistically highly significant (p<0.001).
 Conclusion: Our findings revealed that serum zinc level was significantly lower in children with febrile seizure in comparison with children without seizure.
 Keywords: febrile seizure, children, epilepsy.
Highlights
Febrile seizure is the most common seizure in children
Background: The aim of the present study was to determine whether there were any changes in serum zinc level in children with febrile seizure in comparison with febrile children without seizure
In present study, we studied 50 children (36 males, 14 females) with febrile seizure and a control group of 50 patients (37 male, 13 female)
Summary
Febrile seizure is the most common seizure in children. It occurs in children aged 6 month to 6 years. Zinc regulates the activity of glutamic acid and the rate-limiting enzyme (Glutamic acid decarboxylase) in the synthesis of gammaaminobutyric acid (GABA) which is an inhibitory neuro-transmitter. This element facilitates the inhibitory effect of calcium on N-methyl-D-aspartate receptors (NMDA) and by these effects prevents the stimulation of neuronal discharge. Methods: A prospective observational study was done on 100 children, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions.
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