ROLE OF SERUM URIC ACID LEVELS AND CRP IN THE EXISTENCE OF ATRIAL FIBRILLATION IN HYPERTENSIVE PATIENTS

Abstract

Objective: The inflammatory effect of the serum uric acid and C-reactive protein (CRP) is evident, as well as the role and significance, of inflammation in the presence of atrial fibrillation. The aim of this study was to investigate a possible association between the serum uric acid levels with the existence of atrial fibrillation in hypertensive patients and the possible role of CRP in this status. Design and method: We studied 1196 hypertensive patients (45,1% female), treated or newly diagnosed untreated, of mean age: 63,1 ± 13,3 years, without any known cardiovascular disease and with mean office systolic/diastolic arterial blood pressure (S/DBPo): 142,1 ± 19.3/86.5 ± 12,6 mmHg, mean office heart rate (HRo): 73,7 ± 10,7 bpm, average body mass index (BMI): 28.5 ± 5,8 kg/m2and average waist circumference (WC) 96.1 ± 12.9 cm The levels of serum uric acid (SUA), C-reactive protein (CRP), urea, creatinine,were recorded. eGFR was calculated according Cockcroft-Gault Equation and the atrial fibrillation (AF) status was recorded. The study population was separated in two groups, according the existence or not of any evidence for AF Group A: with PAF or PEAF Group B: without AF By using the ANOVA statistic method we registered the SUA and CRP values in both groups. Using Pearson correlation method we correlated SUA with CRP serum levels. Results: Table 1: Differences of serum uric acid and CRP levels between group A and group B Table 2: Correlation between serum uric acid levels with C-reactive protein levels SUA: serum uric acid CRP: C-reactive protein Conclusions: In hypertensive patients treated or not, the presence of PAF or PEAF was associated with significantly higher serum uric acid levels and CRP levels, while a significant positive correlation exists between SUA and CRP levels in this population. possibly indicating their importance in the inflammatory status of hypertensive patients with atrial fibrillation.