ROLE OF SERUM URIC ACID AS A PREDICTOR OF PREECLAMPSIA IN FIRST TRIMESTER

Abstract

Background: preeclampsia is a unique multisystem disorder of pregnancy leading to increased Maternal mortality in India accounting for 9 % of all maternal deaths.The search for an ideal predictive test for preeclampsia still remains a major challenge for obstetrians. Early diagnosis and management improves maternal and fetal outcome. Objectives: 1)To detect raised levels of serum uric acid during first trimester for early diagnosis and management. 2) To determine the diagnostic efficiency of uric acid as a predictive marker for severity of Preeclampsia. Methods And Methodology: Our study is a prospective cohort study including 200 pregnants attending for regular antenatal checkups in first trimester at our out patient Department during October 2020 to july 2021. After obtaining Informed consent,the selected pregnants were investigated for serum uric acid levels by auto analyser along with other routine blood investigations.These pregnants were regularly followed up once in 4 weeks for 28 weeks then once in two weeks till their delivery for healthy mother and healthy baby outcome. Results: In study, serum uric acid analysis in first trimester for 200 pregnants revealed 92 pregnants had levels >4.2 mg/dl of which 59 were normotensive and 33 pregnants were pre eclamptic. Remaining 108 pregnants had levels <4.2mg/dl. In my study risk for both maternal and fetal complications assessed with serum uric acid levels was P value is 0.0001 which is statistically significant Serum uric acid test Positive (n=92)>4.2 mg/dl Negative (n=108) <4.2mg/dl Preeclampsia frequency Percentage frequency Percentage Absent 59 64 99 91.7 Mild 16 17.4 6 5.6 Severe 16 16.3 3 2.8 Eclampsia 02 2.2 0 0 Conclusion: Assessment of elevated serum uric acid in first trimester was associated with later preeclampsia. Thus serum uric acid estimation is a cost effective,convenient predictor for determination of severity of Pre eclampsia.