ROLE OF SERUM ISCHEMIC MODIFIED ALBUMIN COMBINED WITH HS-TROPONIN T (HS-TNT) IN DIAGNOSIS NON-ST SEGMENT ELEVATION ACUTE CORONARY SYNDROMES

Abstract

Background: Early diagnosis in ACS is significant to treatment and prognosis. It helps to reduce death and complications. What is the value from a combination of IMA and hs-TnT for diagnosing non-ST segment elevation acute coronary syndromes. Objective: To determine the serum concentration of IMA and hs-TnT in patients with non-ST segment elevation acute coronary syndromes. To define sensitivity and specificity when combining IMA and hs-TnT in diagnosis non-ST segment elevation acute coronary syndromes. Subject and Method: 75 patients hospitalized in Hue Central Hospital with breast pain. Diagnosis of non-ST segment elevation acute coronary syndromes is done on 37 of those as in a patients group (ESC in 2015); 38 others are chosen as a controls group. Cross-sectional study with comparison is applied. Result: In 2 tests at different time points, the concentration of hs-TnT and IMA in patients group with non-ST segment elevation acute coronary syndromesis higher compared with that in the controls group (median: 0,065ng/mL > 0,006ng/mL and 0,162ng/mL > 0,0055ng/mL). Average IMA concentration in patients group is 93,49± 89,56 IU/mL (median: 58,57IU/mL) and higher compared with the controls group which reaches15,01 ± 9,87 IU/mL (median:11,735IU/mL). It results in a statistical significance p<0,001. The cut off point of hs-TnT > 0,014ng/mL and IMA>28,68 IU/ML, reaching a sensitivity at 88,9% and a specificity at 100%, AUC = 0,97, p < 0,001, 95% CI= 0,915 – 1,00. Conclusion: Combination of IMA and hs-TnT results in a high value for diagnosis of non-ST segment elevation acute coronary syndromes. Key words: hs-Troponin T, IMA, NSTE-ACS