Abstract
Introduction: Cough variant asthma (CVA) is known by airway Hyper responsiveness and nonproductive chronic cough without wheezing for a minimum duration of 8 weeks. It is less common form of asthma. This study was conducted aiming to diagnose the role of serum Immunoglobulin E (IgE) in diagnosis of cough variant form of the disease. Methods: In this cross sectional study, 80 patients with an age range of 5-14 years were included with clinical criteria for CVA who referred to pulmonology clinic of Tabriz Children Hospital, Tabriz, Iran. Serum IgE level was measured and severity of CVA based on Global Initiative for Asthma (GINA) classification was determined, finally the relationship between serum IgE level and severity of CVA was evaluated. Results: In patients with CVA without history of allergic disease, mean serum titer of IgE was 138.2 ± 17.5. Significant difference of serum IgE level in different severities of CVA was detected (P = 0.001). Conclusion: Serum IgE level in patients with CVA is a reliable marker for diagnosis and evaluation of the severity of disease.
Highlights
In this cross sectional study, 80 patients with an age range of 5-14 years were included with clinical criteria for Cough variant asthma (CVA) who referred to pulmonology clinic of Tabriz Children Hospital, Tabriz, Iran
Serum Immunoglobulin E (IgE) level was measured and severity of CVA based on Global Initiative for Asthma (GINA) classification was determined, the relationship between serum IgE level and severity of CVA was evaluated
Chronic cough is defined as a cough that lasts more than 8 weeks.[2]
Summary
PEF: Peak expiratory Flow; EFR: Expiratory flow rate; FEV: Forced expiratory volume. 6. Normal spirometry finding For diagnosis of CVA, existence of at least two of the above mentioned criteria and chronic cough are necessary.[11] According to Global Initiative for Asthma (GINA) classification, asthma has been divided into four categories based on daily or night symptom and spirometry values: Intermittent, mild persistent, moderate persistent, and severe persistent asthma (Table 1).[12] Based on the knowledge of the researchers, no study has been conducted on the evaluation of serum IgE level and severity of CVA. Based on physical examination and spirometry values and clinical history, patients were divided into four groups based on severity of asthma: intermittent, mild persistent, moderate persistent, and sever persistent asthma, and the serum IgE level was measured among them. Mean of serum IgE level among men and women was 156.0 ± 22.9 and 107.0 ± 26.6 (IU/ml), respectively, and no significant difference was observed between the two groups (P = 0.120). This study indicated that in CVA, the serum Ig E level was high, and it had different level in different severity of disease
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